POLIFILL Stimulates the fibroblast and endogenous hyaluronic acid, influencing the remodeling, lifting and redensification of the skin thanks to its higher concentration of Polynucleotides, than other similar products
2 ml Syringes


Polifill : an innovation in aesthetic and anti-aging medicine. 


Polifill is a product based on active polynucleotides specially designed for skin renewal and bio-restructuring. Nucleofill is a bio-revitalizing product. It is compatible with a mesotherapy protocol. This product is not intended for volume.

This innovative treatment acts on three levels:

  • Lifting
  • Antioxidant
  • Moisturizing.

Polifill provides a significant and lasting rejuvenating effect. 


Polifill is an innovation in aesthetic and anti-aging medicine due to its polynucleotide-based skin bio-stimulation technique.

1- Receptors on skin fibroblasts.

With such stimulation, they transform into myofibroblasts. The production of type I collagen and elastin is stimulated, which results in a thickening and lifting of the skin.

2- Trap free radicals

Nucleofill medium provides a powerful antioxidant action.


3- Binding to water molecules

The polynucleotides bind to water and provide long-term isosmotic hydration of the extracellular matrix. 

The skin gains in deep hydration and firmness.

Indications for Nucleofill Strong:

Skin subject to oxidative stress, lack of oxygen

Dehydrated skin

Stretch marks



Polifill is designed for all skin types, regardless of its maturity:

– Visible rejuvenating effect without affecting facial features

– Reduces the appearance of wrinkles and creases and firms the skin

– Skin exposed to oxidative stress (due to air pollution, sun exposure, smoking, poor diet)

– Dehydrated skin

– Before injections, to extend their aesthetic effects

Polynucleotide gel at 2,5%


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